Molecular Aspects of Herpes Simplex Virus I Latency, Reactivation, and Recurrence
نویسندگان
چکیده
منابع مشابه
Molecular aspects of herpes simplex virus I latency, reactivation, and recurrence.
The application of molecular biology in the study of the pathogenesis of herpes simplex virus type 1 (HSV-1) has led to significant advances in our understanding of mechanisms that regulate virus behavior in sensory neurons and epithelial tissue. Such study has provided insight into the relationship of host and viral factors that regulate latency, reactivation, and recurrent disease. This revie...
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Clinical observations and experimental studies suggested that the relative proportions of ganglionic neuronal intracellular cyclic adenosine monophosphate (c-AMP) and cyclic guanosine monophosphate (c-GMP) concentrations may influence the state or activity of herpes simplex viral DNA in its relationship with the host cell DNA. We studied the effects of putative modulators of intracellular cycli...
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Herpes simplex virus type 1 is a neurotropic herpesvirus that establishes latency within sensory neurones. Following primary infection, the virus replicates productively within mucosal epithelial cells and enters sensory neurones via nerve termini. The virus is then transported to neuronal cell bodies where latency can be established. Periodically, the virus can reactivate to resume its normal ...
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ژورنال
عنوان ژورنال: Critical Reviews in Oral Biology & Medicine
سال: 1998
ISSN: 1045-4411,1544-1113
DOI: 10.1177/10454411980090040901